Syndesmosis of the distal tibiofibular plays an important role in the stability and function of the ankle joint. Injury of distal tibiofibular syndesmosis is often accompanied by fractures of the ankle joint. If the diagnosis and treatment are not timely, it will lead to joint instability and long-term Pain. This article will review the latest research on anatomy, biomechanics, injury mechanism, and clinical diagnosis related to distal tibiofibular syndesmosis injury.