【Abstract】Objective To systematically evaluate the difference in the efficacy and safety of minimally invasive techniques such as percutaneous vertebroplasty, percutaneous kyphoplasty, and vesselplasty in the treatment of osteoporotic vertebral compression fractures. Methods Databases of VIP, Wanfang, PubMed、CNKI、The Cochrane library、EMBASE、CBM were searched by computer， supplemented by manual retrieval of existing magazines, collected randomized controlled trials on percutaneous vertebroplasty (PVP), percutaneous kyphoplasty (PKP), vesselplasty for the treatment of osteoporotic vertebral compression fractures, with the retrieval time up to January 2020. After two researchers independently selected literature, extracted data and evaluated the quality of the included study, gemtc 0.14.3 software was used to conduct network meta-analysis of the included study. Results 11 studies were included in this analysis, including 1356 patients. Results The network meta-analysis showed that: (1) In terms of reducing the VAS score, there was no statistical difference between the two groups (P＞0.05), and the order from the best to the worst was as follows: Vesselplasty＞PVP＞PKP; (2) In terms of reducing the ODI score, there was no statistical difference between the two groups (P＞0.05), and the order from the best to the worst was as follows: Vesselplasty＞PVP＞PKP; ③In terms of reducing Cobb angle, Cobb angle of PKP was lower than that of PVP [MD = 8.53, 95% CI (2.61, 14.39)] , there was no significant difference between the other two groups (P > 0.05), and the order from the best to the worst was as follows: PKP＞Vesselplasty＞PVP.④In terms of reducing the leakage rate of bone cement, the leakage rate of bone cement of Vesselplasty was lower than that of PKP [OR=0.14，95%CI(0.01, 0.52)], and the leakage rate of bone cement of Vesselplasty was lower than that of PVP [OR=0.06 ，95%CI(0.00, 0.51)], there was no significant difference between the other two groups (P > 0.05), and the order from the best to the worst was as follows: Vesselplasty＞PKP＞PVP. Conclusion Based on the results of network meta-analysis and probability ranking of VAS score, ODI score, Cobb angle of injured vertebrae, leakage rate of bone cement and other aspects, vesselplasty may be the first choice for the treatment of OVCF. 【Keep Words】 percutaneous kyphoplasty；vesselplasty；percutaneous vertebroplasty；osteoporotic vertebral com-pression fracture；network meta-analysis