Objective:The purpose of this study was to evaluate and compare the postoperative CRP, PCT counts, and ESR after UKA and TKA,which was proved to be non-infection. Method: Fourty-nine patients of UKA and fourty-seven patients of TKA which were proved to be non-infection from january 2017 to december 2018 were enrolled in this study.Blood samples of CRP、PCT and ESR were obtained before surgery and postoperative day (POD) 1, POD3, and POD6.All datas between groups over time were assessed. Results: Changes in CRP between UKA and TKA groups over time were both statistically significant(p＜0.05), respectively.The percentage of PCT elevation in the TKA group was significantly higher than that in the UKA group on the first day after surgery.However, no significant difference was found in ESR over time. Conclusions: For medial compartment osteoarthritis, we found that a lower CRP peak with faster recovery of CRP kinetics was observed after UKA.We further proves that UKA has the advantages of less trauma and low inflammatory response from the perspective of hemodynamics of blood infection indicators.