Abstract: [Objective] To systematically evaluate the efficacy and safety of percutaneous curved vertebroplasty and bilateral pedicle approach percutaneous vertebroplasty in the treatment of osteoporotic Vertebral compression fracture. [Methods] Using computer to search EMBASE、PubMed、Cochrane Library、CNKI、WanFang and CBM before January 2020, we collected the randomized controlled trials about the treatment of osteoporotic vertebral compression fracture by vertebroplasty with curved angle and vertebroplasty with bilateral pedicle approach. After literature screening, data extraction and quality evaluation by two evaluators, we used Revman 5.1 to carry out meta analysis.[Results] A total of 6 randomized controlled trials were conducted, including 428 patients, of whom 217 were treated with percutaneous curved vertebroplasty and 211 with bilateral pedicle approach percutaneous vertebroplasty. The results of meta analysis show that the difference of Postoperative VAS score[MD=-0.12，95%CI（-0.21，-0.04）、 leakage rate of bone cement[RR=0.36，95%CI（0.18，0.75），P＝0.006]、X-ray exposure times[MD=-9.35，95%CI（-10.68，-8.02），P＜0.05]、injection volume of bone cement[MD=-1.58，95%CI（-1.89，-1.28），P＜0.05]、operative time[MD=-14.93，95%CI（-18.12，-11.73），P＜0.05]between percutaneous curved vertebroplasty and bilateral pedicle approach percutaneous vertebroplasty was statistically significant.[Conclusions] percutaneous curved vertebroplasty is better than bilateral pedicle approach percutaneous vertebroplasty in analgesic effect and safety of operation