Abstract:[Objective] To investigate the clinical effect of wrist arthroscopy assisted percutaneous screw internal fixation in the treatment of scaphoid fracture. [Methods] 86 patients with scaphoid fracture admitted to our hospital from February 2014 to December 2017 were randomly divided into control group and observation group, 43 cases in each group. The control group was treated with closed reduction under fluoroscopy and percutaneous screw internal fixation, while the observation group was treated with wrist arthroscopy assisted percutaneous screw internal fixation. The operation indexes, Cooney wrist joint score and clinical efficacy of the two groups were compared. [Results] There was no significant difference in hospital stay between the control group and the observation group (4.12±0.51) vs (3.91±0.59) d (P>0.05). The operation time and callus score at 3 months after operation in the observation group were more than those in the control group (54.37±7.03) vs (43.19±5.82) min, (3.84±0.46) vs (3.18±0.37)points, and the fracture healing time was less than those in the control group (11.06±1.29) vs (13.27±1.65) weeks, the difference was statistically significant (P<0.05). Before operation, there was no significant difference in Cooney''s wrist score between the two groups (P>0.05). After operation, Cooney''s wrist joint score in both groups was higher than that before operation, and that in the observation group was higher than that in the control group, the difference was statistically significant (P<0.05). The excellent and good rate in the observation group was 97.67% vs 83.72% higher than that in the control group (P<0.05). [Conclusion] Wrist arthroscopy assisted percutaneous screw internal fixation is effective for scaphoid fracture, and has the characteristics of short fracture healing time, good wrist function recovery effect and high safety.