Abstract:［Objective］To compare the curative effect of transforaminal lumbar interbody fusion (TLIF) combined with fenestration decompression on the other side and the posterior lumbar interbody fusion (PLIF) for the treatment of lumbar spinal canal stenosis with bilateral nerve symptoms.［Methods］Patients with bilateral neurological symptoms of lumbar spinal stenosis hospitalized in the 960 Hospital of PLA of Taian from February 2014 to March 2015.Among them，32 cases underwent TLIF combined with contralateral fenestration decompression (TLIF+ fenestration group) ，32 cases underwent PLIF operation，record the general condition， length of hospital stay and operation, blood loss, drainage volume, complication rate and fusion rate were recorded.Oswestry Disability Index score (ODI) and Visual Analog Scale (VAS),intervertebral space height and local sagittal Cobb angl were performed preoperatively, 2 weeks, 3 months, 6 months and At last follow-up postoperatively.［Results］Postoperative follow-up ranged from 25 to 38 months, with an average of 27.2 months.The hospitalization and operation time, blood loss and drainage volume of TLIF + fenestration group were lower than those of PLIF group，the difference was statistically significant（P<0.05）.There were no significant differences in the incidence of complications, ODI and VAS scores, intervertebral space height, and local sagittal Cobb angle(P>0.05).ALL the intervertebral space were fused.［Conclusion］TLIF + fenestration and PLIF are effective methods for the treatment of bilateral neurological symptoms of lumbar spinal stenosis.The hospitalization and operation time, bleeding volume and drainage volume of TLIF + fenestration group were less than those of PLIF group, which was a safe and effective surgical method.