Abstract：[Objective] To investigate the clinical efficacy of enhanced recovery after surgery oncept-multiple analgesia in the postoperative elderly patients with posterior lumbar interbody fusion (PLIF). [Methods] From June 2018 to August 2018, 80 elderly patients who underwent posterior lumbar fusion surgery in our department (age: >65 years old) were randomly divided into two groups, group A and group B. Group A (experimental group) : in 40 patients, 0.5% ropivacaine was used to perform local infiltration anesthesia from deep to shallow in the operation area;Group B (control group) : 40 patients received preoperative intravenous controlled analgesia pump or daily oral administration of celecoxib 72h before surgery for advanced analgesia. The enhanced recovery after surgery concept-multiple analgesia in the postoperative lumbar interbody fusion of elderly patients was evaluated by observing the Visual analogue scale (VAS) , the time of adding analgesics for the first time after surgery, the dosage of additional analgesics, the incidence of adverse reactions and the satisfaction of patients of the two groups patients. [Results] There were no statistically significant differences in preoperative general clinical data, operative time, and blood loss between the two groups (P>0.05).Visual analogue scale of the experimental group at 6h, 12h, 24h, 48h and 72h after surgery were significantly lower than those of the control group, with statistically significant differences (P<0.01).There were statistically significant differences between the two groups in the time of the first postoperative addition of analgesics, the amount of analgesics and the incidence of adverse reactions (P<0.05).The satisfaction of patients in the experimental group was 95%, while that of patients in the control group was 75%. The difference between the two groups was statistically significant (P<0.05). [Conclusion] Ropivacaine around the incision infiltration local analgesia mode can significantly reduce the pain of elderly patients with posterior lumbar fusion surgery, reduce the additional analgesic time for the first time, increase the dosage of analgesic drugs and adverse reactions occur, significantly improve patients with postoperative satisfaction, and clinical therapeutic effect was satisfied.