[Objective] To assess the efficacy of superior vertebral pedicle notch approach of transforaminal percutaneous endoscopic lumbar discectomy for high-grade inferior migrated disc herniation. [Methods] The clinical data of 36 patients with high-grade inferior migrated disc herniation operated with percutaneous endoscopic surgery via the superior vertebral pedicle notch approach from April 2016 to January 2018 were retrospectively analyzed. The leg pain visual analogue scale (VAS of leg pain), the Oswestry Disability Index (ODI) and Japanese Orthopaedic Association Scores (JOA) were compared before operation and 1 month, 6 months, 12 months and 18 months after operation, respectively. The clinical results were assessed at each time point of follow-up by using modified Macnab criteria. Complications were recorded during follow-up, and postoperative X-ray, CT and MRI examinations were performed. [Results] All patients completed a 18-month follow-up assessment after surgery. The mean operative duration was 68.82±14.64 min, and hospital stay time was 3.21±0.63 days. The symptoms of the patients were significantly relieved after the operation, and the VAS score, ODI score, and JOA score at each time point after follow-up were significantly better than those before operation (P<0.05). On the basis of the modified MacNab criteria, the excellent and good rates at 1, 6, 12 and 18 months after surgery were 83.33%, 88.89%, 91.67%, and 94.44%, respectively. Two patients (5.56%) had transient dysesthesia after surgery. Postoperative radiological evaluations showed no signs of instability or recurrence of pathology. [Conclusion] Transforaminal percutaneous endoscopic lumbar discectomy can achieve good clinical effects in the treatment of high-grade inferior migrated disc herniation. It has the advantages of less trauma, shorten hospital stay and quick postoperative recovery.