Abstract：［Objective］ To investigate the clinical effect of tibial transverse transport technique combined with negative pressure closed drainage（VSD）in the treatment of diabetic foot ulcers.［Methods］ From April 2017 to June 2019，45 patients with diabetic foot ulcers were divided into groups according to the treatment methods.23 patients underwent tibial transverse transport technique combined with negative pressure closed drainage（VSD group），22 patients were treated only by tibial transverse transport technique（control group）.VAS score，ankle brachial index，skin temperature of affected limb，and healing time of ulcer of diabetic foot ulcers were recorded after treatment.［Results］ Both groups underwent successful operation，The VAS score，ankle-brachial score，and the skin temperature of the affected limb after operation at 1 and 3 months were significantly improved compared with those before operation，and the difference was statistically significant（P＜0.05）.By comparison between the two groups after operation at 3 months，the VAS score were compared between the two groups,the difference was not statistically significant（P＞0.05）.ankle-brachial score and the skin temperature of the affected limb of VSD group improved more significant than control group,the difference was statistically significant（P＜0.05），The healing time of ulcer wounds of VSD group were shorter than control group,the difference was statistically significant（P＜0.05）.［Conclusion］ The clinical efficacy of tibial transverse transport technique combined with negative pressure closed drainage in the treatment of diabetic foot ulcers is satisfactory，negative pressure closed drainage can effectively relieve limb pain，improve microcirculation of affected limbs，promote the growth of granulation tissue on wound surface and accelerate the healing of ulcer wounds.