to investigate the clinical effect of ankle arthroscopy combined with platelet-rich plasma in the treatment of talus cartilage injury. Methods: from January 1, 2018 to October 31, 2019, 32 cases of talus cartilage injury were treated with ankle arthroscopy combined with platelet-rich plasma, including 18 males and 14 females, with an average age of 45.3 years (28 ≤ 63 years), 18 patients with lateral talus injury, 9 patients with stage IV talus injury, 5 patients with stage V, 2 weeks after operation, no load-bearing joint activity, and wearing protective gear one month after operation. 3 months after operation, the weight was completely loaded, and every 3 months after operation, the weight was reexamined at the same time. Kofoed ankle function scoring system and MRI were evaluated again. Results: one of 32 patients was followed up for an average of 6.3 months. The symptoms of ankle swelling and pain disappeared in the last follow-up. Kofoed ankle function score was (79.13 ±3.27) before operation and (92.13 ±2.58) after operation, which showed that bone marrow edema disappeared in 10 cases, edema range decreased in 18 cases, and bone marrow edema scope did not decrease significantly in 3 cases. Conclusion: arthroscopic ankle arthroscopy combined with platelet-rich plasma is a method for the treatment of talus cartilage injury. a feasible and effective surgical procedure.