[Abstract] Objective To investigate the surgical technique and clinical effect of posterior lumbar interbody fusion (PLIF) assisted by self-made lumbar spondylolisthesis reduction device in the treatment of lumbar spondylolisthesis with osteoporosis. Methods From June 2017 to December 2018, 21 patients with lumbar spondylolisthesis and osteoporosis were treated with PLIF assisted by self-made lumbar spondylolisthesis reduction device.There were 4 males and 17 females.The age of the patients ranged from 53 to 76 years old, with an average age of 63.1 (62.90±5.32) years. After screw placement and spinal canal decompression are completed, the reduction retractor is hooked to the connecting part of the transverse process on both sides of the severely slipped vertebral body and the upper articular process respectively. The adjusting handle is pressed, the traction handle is then moved backward, and the connector drives the reduction retractor to be pulled backward, thus reducing the spondylolisthesis, and intervertebral fusion is performed. Results Twenty-one patients successfully completed the operation, and all the 21 patients were healed in stage I after the operation,One patient was found to have transverse process splitting during the operation, and one patient was found to have disappeared from anticoagulation treatment for left lower extremity posterior tibial vein thrombosis after the operation, while the other patients had no serious complications. All patients were followed up for (14.01±2.18) months. The average slippage reduction rate was 97.52%±4.06%. The slip distance, VAS score of lower limbs, VAS score of waist and back, and ODI score at each time point after the operation were significantly improved compared with those before the operation, and the difference was statistically significant（p＜0.05）. Conclusion The PLIF surgery assisted by the self-made spondylolisthesis reduction device has a good short-term effect, a safe and effective method for the reduction of lumbar spondylolisthesis. It is an alternative treatment for patients who suffered from lumbar spondylolisthesis with osteoporosis.