Objective: To study the relationship between blood sugar, hypersensitive c-reactive protein (hs-CRP), homocysteine (Hcy) level and degree of trauma in patients with traumatic fracture. Methods: 72 patients with traumatic fracture admitted to our hospital from January 2019 to October 2019 were selected. The patients were divided into 36 mild trauma groups, 28 severe trauma groups and 9 severe trauma groups according to the trauma severity (ISS) score, and 68 healthy physical examination patients in our hospital during the same period were selected as the control group. The levels of blood sugar, hs-CRP and Hcy in each group were compared, and the relationship between the above indexes and ISS score in patients with traumatic fracture was analyzed. Results: The blood sugar, hs-CRP and Hcy levels in traumatic fracture group were higher than those in control group at all time points (P<0.05). The levels of blood sugar, hs-CRP and Hcy on the 1st day after operation in the traumatic fracture group were higher than those before operation, and the levels of blood sugar, hs-CRP and Hcy on the 3rd and 7th days after operation were decreased, the difference was statistically significant (P<0.05). The levels of blood sugar, hs-CRP and Hcy in severe trauma group were higher than those in severe trauma group and mild trauma group (P<0.05). The levels of blood sugar, hs-CRP and Hcy on the 1st day after operation in each group were higher than those before operation, and the levels of blood sugar, hs-CRP and Hcy on the 3rd and 7th days showed a downward trend (P<0.05). Blood sugar, hs-CRP and Hcy levels in patients with traumatic fracture were positively correlated with ISS score. Conclusion: The dynamic changes of blood sugar, hs-CRP and Hcy in patients with traumatic fracture are related to the degree of body trauma and play an important role in judging the condition of bone trauma.