Abstract Objective To explore the clinical effect of minimally invasive percutaneous cannulated screw in the treatment of sacroiliac joint dislocation combined with pubic fracture. Methods From January 2014 to December 2018, 65 patients with pubic fracture and sacroiliac joint injury were selected, including 34 patients (control group) treated by reduction and internal fixation via ilioinguinal approach and 31 patients (observation group) treated by minimally invasive percutaneous screw fixation. The bleeding, operation time, times of fluoroscopy and complications were analyzed, and the VAS and Majeed scores were evaluated. Results (1)The bleeding and complications in the control group than in the observation group, the difference was statistically significant (P < 0.05), and the operation time and times of fluoroscopy in the observation group were more than in the control group, the difference was also statistically significant (P < 0.05).(2) The VAS score of the control group was significantly higher than that of the observation group on the first day and the first month of follow-up (P < 0.01), and there was no significant difference in the VAS score of the three months after operation (P > 0.05).(3)The average Majeed score of the observation group was significantly higher than that of the control group (P < 0.05). (4) At 6 months after operation, the excellent rate of Majeed score was 93.54% in the observation group and 61.76% in the control group, the difference was statistically significant (x2 = 8.085, P = 0.044).(5)The excellent rate according to the Matta classification of the observation group was 94.11% (32 / 34) and that of the control group was 96.77% (30 / 31), there was no significant difference between the two groups (P < 0.05).