Objective:To study the effects of interrupted suture and intradermal suture on wound healing after total knee arthroplasty (TKA). Methods: 90 patients including 18 males and 72 females who underwent TKA at the Jining No.1 People’s Hospital from October 2016 to March 2018 were divided into interrupted suture group and intradermal suture group by the intentions of the patients themselves’ .All patients who aged ( 63 ± 5) years averagely, have a negative rheumatoid factors (RF) and a negative antistreptolysin-O. Also, their C-reaction protein is less than 5mg/L, as well as their erythrocyte sedimentation rate is slower than 20mm/h. The suture time, postoperative hospital stay, times of dressing and patients’ satisfaction between the two groups were compared. And the number of suture reaction, fat liquefaction, misaligned involution of incision, infected cases within 1 year, and unprimarily healed incisions were included in the comparison as well. Results: The intradermal suture group had a less postoperative hospital stay, better patients’ satisfaction and less suture reaction than interrupted suture group with a significant difference. While variations were also found on the other evaluating indicators between the two groups, but they did not differ statistically. Conclusion: Compared with interrupted suture, the intradermal suture might promote wound healing after TKA with a less chance of complication. Intradermal suture could be an effective way of incision closure for TKA.