Objective To explore the correlation between thrombotic events after knee joint replacement and changes in c-reactive protein (CRP), platelet (PLT) and hemoglobin (HGB), and to put forward countermeasures to reduce the incidence of thrombotic events. Methods A retrospective analysis was conducted on 129 patients who underwent artificial joint replacement in a hospital from January 2017 to August 2018. Among them, 32 patients with thrombotic events were selected as the observation group and 97 patients without thrombotic events as the control group. Univariate and Logistic regression models were used to explore the independent influencing factors of thrombotic events after knee joint replacement using 1 indicator including gender, age, duration of surgery, intraoperative blood loss, type and duration of prophylactic antibiotics, use of anticoagulants, preoperative and postoperative changes of PLT, CRP, HGB, WBC and PCT. Results Univariate analysis (x2 test) showed that the composition of postoperative HGB, postoperative WBC, preoperative PLT, preoperative CRP, preoperative antibiotics and postoperative antibiotics was significantly different between the thrombotic event group and the non-thrombotic event group (P<0.05). Multivariate logistic regression analysis showed that postoperative HGB, preoperative PLT and preoperative CRP were independent influencing factors of thrombotic events. Conclusion The incidence of thrombotic events after knee joint replacement is correlated with the level of preoperative platelet, postoperative CRP and HGB. Therefore, it is an effective measure to improve preoperative auxiliary examination and evaluation, strengthen postoperative monitoring and actively prevent anticoagulant intervention to prevent postoperative thrombotic events of knee joint.