[Objective] To investigate the feasibility and clinical outcome of minimally invasive percutaneous pedicle screw fixation (MIPS) combined with PKP in the treatment of osteoporotic thoracolumbar burst fractures without neurological symptoms. [Methods] Retrospective analysis of 30 patients with non-neuropathic osteoporotic thoracolumbar burst fractures from March 2015 to March 2018, including 13 males (mean 60-73 years old) and 27 females (mean 65.7 years old). The intraoperative complications, intraoperative blood loss, operation time, total hospitalization time, VAS score before and after surgery, ODI index, Cobb angle of kyphosis correction, and height recovery of injured vertebrae were statistically analyzed. [Results] The operation time was about 53.5±15.6 min, the bleeding volume was about 30.8±8.5 ml, and the total hospitalization time was 4.5±1.2 days. The incision healed well after discharge. There were statistically significant differences in VAS score, ODI index, kyphosis correction Cobb angle and vertebral body height preoperation and post-operation (P < 0.05). [Conclusion] MIPS combined with PKP has the short-term advantages of minimally invasive, less bleeding, and faster healing. It is an ideal surgical option for the treatment of osteoporotic thoracolumbar burst fractures without neurological symptoms, but the long-term efficacy needs further follow-up observation.