Abstract Objective To observe the effect of intraincision perfusion combined with repeated intravenous application of tranexamic acid on blood loss and safety in the operation of degenerative lumbar scoliosis. Methods From April 2015 to April 2019, 97 patients with lumbar degenerative scoliosis were randomly divided into control group, simple vein group and combined application group. Among them, 32 cases in the control group (no TXA in perioperative period) and 33 cases in the simple vein group (15 mg / kg of TXA in 30 minutes before operation). 32 cases in the combined application group (intravenous drip of TXA 15 mg / kg at 30 minutes before operation + intraincision perfusion of TXA 1.0 g solution 10 ml after operation + intravenous drip of TXA 15 mg / kg at 6 hours after operation). Results ① there was no significant difference in the basic data, operation time and the number of lumbar segments in the three groups (P > 0.05). (2) the amount of intraoperative bleeding, autotransfusion and allogeneic red blood cell input in the combined application group and the simple vein group were significantly less than those in the control group, with significant statistical significance (P < 0.01), and there was no significant difference between the combined application group and the simple vein group (P > 0.05). ③ the combined application group of postoperative induced flow and postoperative recessive blood loss of three groups was significantly less than that of the single vein group and the control group (P < 0.01), and there was no significant difference between the single vein group and the control group (P > 0.05). ④ the difference of DD dimer in the three groups was statistically significant (P < 0.05), while that in the combined application group 72 hours after operation was statistically significant (P < 0.05). Conclusion Intraincision perfusion combined with repeated intravenous application of tranexamic acid could significantly reduce the total blood loss of patients with DLS during the perioperation, which is conducive to the rapid recovery of patients without increasing complications such as deep vein thrombosis.