Osteogenesis imperfecta (OI), also known as brittle bone disease, is a kind of connective tissue disease caused by genetic or gene mutations. It is mainly characterized by low energy fracture, bone loss, teeth dysplasia, blue sclera, excessive joint laxity, progressive deafness, newborn beads, osteoporosis and skull closed anomaly [1].The essence of OI lies in the changes of bone, ligament, dentin and sclera morphology caused by abnormal type I collagen structure [2].Patients with OI are also manifested as scoliosis, humpback, craniocervical junction abnormalities (basilar depression and basilar flat), lumbosacral lesions (spondylolisthesis) [3, 4], and other complications including cardiopulmonary dysfunction [5], valvular and aortic diseases [6].OI combined with scoliosis and limb deformity are more common, but OI combined with lumbar disc herniation is relatively rare and rarely described in the literature.We report a case of OI combined with lumbar disc herniation who underwent percutaneous endoscopic discectomy with selective local anesthesia.