[Abstract] Objective: To investigate the clinical application of Mimics software in the treatment of clavicular fractures. Methods: Seventy patients with clavicular fractures treated in our hospital from July 2016 to September 2019 were enrolled. The patients were divided into experimental group and control group according to the random number table method. The control group was treated with conventional surgery. In the clavicle fracture, the experimental group used Mimics software to assist minimally invasive treatment of clavicular fractures. The patients were followed up for 6 months. Visual analog scale (VAS) was used to assess the degree of pain in the patient. The shoulder joint function Neer score was used to evaluate the recovery of the shoulder joint. The intraoperative conditions (surgery operation time, intraoperative blood loss, fluoroscopy) and hospitalization were compared between the two groups. Time, and compare the VAS score and Neer score of the two groups before, 3, and 6 months after surgery. Results: The operation time, intraoperative blood loss, number of fluoroscopy, and hospitalization time in the experimental group were significantly lower than those in the control group, and the difference was statistically significant (P<0.05). There was no significant difference in the preoperative VAS score and Neer score between the experimental group (P>0.05). The VAS score of the experimental group was significantly lower than that of the control group at 3 days after operation. The Neer score of the experimental group was significantly higher than that of the control group at 3 days after operation and 6 months after operation (P<0.05). The VAS scores of the two groups were significantly lower than those before surgery at 3 days after surgery and 6 months after surgery. The Neer score was significantly higher at 3 days after surgery and 6 months after surgery than before surgery. The difference was statistically significant (P< 0.05). The incidence of complications in the experimental group was 2.86%, which was significantly lower than that in the control group (22.86%). The difference was statistically significant (P<0.05). Conclusion: Using Mimics software to assist minimally invasive treatment of patients with clavicular fracture can effectively reduce the operation time, intraoperative blood loss, number of fluoroscopy, hospitalization time, reduce the pain of patients, improve the shoulder joint of patients, and reduce postoperative complications. The occurrence of the disease can be promoted in clinical use.