Abstract: [Objective] to observe the effect of low negative pressure closure drainage (VSD) combined with platelet rich plasma (PRP) on large area skin degloving injury of upper extremity. [Methods] from January 2014 to June 2018, the patients with large area skin avulsion injury of upper extremity in our department were divided into VSD + PPP group and VSD group according to whether to use PRP or not, 32 cases in VSD + PRP group and 28 cases in VSD group. VSD group patients were treated with low negative pressure (50-80mmHg) VSD after debridement and medium thickness skin grafting; VSD + PRP group patients were treated with PRP prepared during debridement and then treated with VSD group patients. The VSD device was removed 7 days later in both groups. The skin survival rate, partial skin necrosis rate, hospitalization time, dressing change times after skin grafting, suture removal time, skin pigmentation rate, skin contracture rate, scar hyperplasia rate, skin edge infection rate, skin necrosis rate (skin necrosis area greater than 50% of skin grafting area is skin flap necrosis) and subcutaneous hematoma rate were recorded. [results] the skin survival rate, partial skin necrosis rate, hospitalization time, dressing change times and suture removal time of VSD+PRP group were better than those of VSD group (P < 0.05), with statistical significance; the skin pigmentation rate, skin contracture rate, scar hyperplasia rate, skin edge infection rate, skin necrosis rate and subcutaneous hematoma rate of VSD+PRP group were higher than those of VSD group. There was no statistical significance (P > 0.05). [Conclusion] the application of medium thickness skin flap replantation combined with 50~80mmHg negative pressure sealing drainage combined with platelet rich plasma can improve the skin survival rate, reduce the necrotic area of some skin grafts, shorten the hospitalization time of patients, reduce the frequency of dressing change after skin grafting, and shorten the time of line removal, which is worthy of clinical application.