Abstract: [Objective] A finite element anatomical model of the mild OA knee joint was constructed and used to study the stress distribution characteristics of the OA knee joint cartilage and meniscus. [Method] Based on MRI and CT image data, a finite element anatomical model of mild OA knee joint with bony and non-bone structures was constructed. The material properties were defined and the boundary conditions and axial loads were determined. The Mises stress of the cartilage contact between the patellofemoral joints was determined. And the contact pressure is the research index, and the stress distribution characteristics in the joint are analyzed. [Results] A three-dimensional finite element anatomical model of the mild OA knee joint was constructed. The results of finite ele-ment analysis showed that the proximal femoral articular cartilage contact pressure was stronger than the lateral chamber, and the lateral meniscus contact pressure peak was larger than the medial chamber; the distal femur and the proximal femoral articular cartilage edge The Mises stress peak is greater than the cartilage contact between the patellofemoral joints. The maximum Mises stress of the lateral meniscus is in the middle of the meniscus, while the maximum Mises stress of the medial meniscus is located in the posterior part of the meniscus.[Conclusion] The stress distribution characteristics of OA knee joints are different from those of normal knee joints. The characteristics of medial meniscus subluxation and articular cartilage degeneration promote the further development of knee OA. The results of finite element analysis provide a biomechanical basis for early treatment and delay of knee OA through stress dispersion and other measures.