objective to investigate the clinical effect of arthroscopic peripatellar deneuralization on anterior knee pain. Methods 50 patients with anterior knee pain were randomly divided into the experimental group and the control group (25 cases each). The control group received arthroscopic arthrodesis, and the experimental group received peri-patellar deneuralization treatment on this basis. The follow-up period was 4-8 months. Lysholm knee function score, visual simulation score, patella Kujala score and proprioception of knee joints were compared between the two groups, and the changes of score were analyzed. Results 4 months after surgery, there was no significant difference in scores between the two groups. 8 months after surgery, Lysholm knee function score, visual simulation score and patella Kujala score in the experimental group were significantly higher than those in the control group (P<0.05). There was also a significant improvement compared with that before surgery. Conclusion arthroscopic cleaning of the knee joint can significantly improve the curative effect of anterior knee pain. The excellent and good rate of knee arthroscopy was significantly improved after 8 months.