Objective: To analyze the effect of computer-assisted internal fixation with locking plate of volar column of distal radius in patients with AO C type distal radius fractures. Methods: The clinical data of 85 patients with distal radius fractures of type AO C were retrospectively analyzed. Among them, 41 cases were treated with open reduction and plate internal fixation, and the remaining 44 cases were treated with computer-assisted locking plate internal fixation of volar column of distal radius, which was recorded as group B. The operation indicators, istal metacarpal inclination, ulnar deviation and wrist motion of affected and contralateral radius 12 months after operation and wrist mobility before and after 12 months of operation and the incidences of complications within 12 months after operation were compared between the two groups. Results: The amount of bleeding during operation in B group was less than that in the A group (P < 0.05), and the duration of operation was shorter than that in the A group (P < 0.05). There was no significant difference in hospital stay and wrist weight-bearing time between the two groups (P > 0.05). There was no significant difference in the palmar inclination, ulnar deviation, wrist dorsal extension, palmar flexion, ulnar deviation and radial deviation between the two groups at 12 months after operation (P > 0.05). There was no significant difference in the palmar inclination, ulnar deviation, wrist dorsal extension and palm between the affected side and the healthy side in group B (P > 0.05). There was no significant difference in the palmar inclination, ulnar deviation, wrist dorsal extension and palm in group B. The flexion, ulnar deviation and radial deviation were higher than those in group A (P < 0.05). There were significant differences in the distribution of wrist function recovery effect and the excellent and good rates between the A group and the B group (P < 0.05). The incidence of complications within 12 months after operation in group B was similar to that in group A (P > 0.05). Conclusion: The treatment of AO C type distal radius fractures with computer-assisted locking plate of palmar column of distal radius can reduce trauma, shorten operation time, improve the palmar inclination, ulnar inclination and wrist motion of distal radius, and ensure good recovery of wrist function with good safety.