[Objective] To investigate the effect of pressurizing cold therapy combined with tranexamic acid injection on the early local symptoms after total knee arthroplasty(TKA), and to clarify its effectiveness and safety in promoting postoperative rehabilitation after TKA. [Methods] A total of 90 patients with end-stage knee osteoarthritis ,who were going to undergo total knee arthroplasty. The patients were divided into three groups named Group A, Group B, Group C according to designing by random control test. Each group included 30 patients respectively were carried different measures after receiving 1.0 g intravenous tranexamic acid. The patients in Group A had 10 ml normal saline injected into the articular cavity before incision suture. The patients in group had 10 ml normal saline with 1.0g tranexamic acid injected into the articular cavity before incision suture. The patients in group C use a new type of cryotherapy device when they go back the ward immediately apart from the same treatment as Group B. We would note the following demographic details of the all patients: pain score on the postoperative 24th,48th hours, thighs swelling degree on postoperative 3rd and 7th day, the active joint range of motion on the postoperative 3rd day, at discharge, 3rd month, knee joint function score, total days in hospital, numbers of patient with complications who had deep vein thrombosis of lower extremity, skin frostbite. [Results] To compare some date as pain score on the postoperative 24th,48th hours, thighs swelling degree on postoperative 3rd and 7th day, the active joint range of motion on the postoperative 3rd day, at discharge, 3rd month, knee joint function score, total days in hospital. The results are significant.(P<0.05). None of number patient with complications such as deep vein thrombosis and skin frostbite were found in 3 months follow-up. [Conclusion] Pressurized cold therapy combined with tranexamic acid injection can improve local symptoms such as swelling and pain in the early stages after total knee arthroplasty, increase joint activity, improve knee function score, reduce hospitalization days, promote early functional rehabilitation, and improve patient quality of life. And does not increase the incidence of postoperative thrombosis and other complications; It is a safe and effective measure to accelerate the recovery after total knee arthroplasty.