【Abstract】 Objective To explore the effect of minimally invasive skin flap combined with vaccum sealing drainage (VSD) in the treatment of Morel-Lavalle injury.Methods From July 2016 to July 2018, a retrospective analysis was made for 34 cases of Morel-Lavalle injury treated by minimally invasive vaccum sealing drainage. Palpation and color Doppler ultrasonography were preoperatively used to determine and mark the extent of exfoliation. During the operation, minimally invasive incision was performed at the proximal and distal drainage areas of the injured area for about 3 cm. After drainage, necrotic tissue was removed with a curette, and then a 5 cm-wide vaccum sealing drainage material strip was inserted under the skin. The drainage tube is arranged in a 5-10 cm width. The drainage tube is drawn out from the proximal and distal incisions respectively, and the incision is covered with vaccum sealing drainage. After 5 to 10 days of drainage, the VSD device was pulled out according to the amount and the characteristics of the drainage fluid, and the incision was sutured in all layers.Results All cases were treated within 3 weeks of injury without secondary infection or incision nonunion. Follow-up for 3 months and 6 months showed that the appearance of exfoliated area,skin sensation and elasticity were basically normal. Conclusion Minimally invasive incision combined with vacuum sealing drainage is an effective method to treat Morel-Lavalle injury.