【Abstract】 Objectives: To investigate the occurrence and prevention of early complications of Stand-alone oblique lateral interbody fusion (OLIF); Methods: From August 2017 to December 2018, total 96 consecutive patients undergoing Stand-alone OLIF were retrospective analyzed. There were 44 males and 52 females with an average age of 3-86years. The follow-up period was 3-20 months; All complications and related treatments intra—operative and post—operative were observed and recorded. Postoperative Radiographic outcomes were used to determine the location of cage, endplate damage and contralateral nerve roots. Clinical outcomes were evaluated using visual analogue scale(VAS)and Oswestry disability index(ODI)．Results: A total of 137 segments of Stand alone OLIF were performed in 96 patients, with an average operation time of 94.10 ± 25.95 min. The mean intraoperative blood loss was 48.41 ± 9.97 ml. The average length of hospital stay was 6.01 ± 2.51 days., All patients had no blood transfusion intra—operative and post—operative. The VAS for back pain and leg pain and ODI scores were decreased appatently for each patient. There were 36 complications occurred intra—operative and post—operative. Four of the patients developed two complications， in fact, Complications occurred in 32 patients, and the complication rate was 33.33%. Among them, 19 cases occurred in single-segment operation, the incidence rate was 28.36%, and 12 cases occurred in double-segment operation, the incidence rate was 44.44%, 1 The patient developed in a three-segment operation with an incidence of 50.00%. Conclusion: In the early stages of development of the Stand-alone OLIF technology, the complications associated with the cage need to be highly concerned. For osteoporosis, intraoperative endplates Intensive patients were followed closely. The short-term efficacy was satisfactory , we also need our long-term follow-up and prospective studies to observe the long-term efficacy and complications of Stand-alone OLIF technology.