Abstract:［Objective］To investigate the clinical effect of personalized tourniquet inflation pressure setting by color Doppler ultrasound in total knee arthroplasty. [Methods] 71 patients with unilateral total knee arthroplasty from March 2017 to August 2017 under general anesthesia were randomly divided into two groups. 35 cases in the control group (fixed pressure group) were treated with fixed tourniquet pressure (270 mmHg); The experimental group (personalized pressure group) consisted of 36 cases. Portable color Doppler ultrasound probe was placed in the popliteal artery. When the peak of popliteal artery blood flow disappeared completely, the inflatable pressure was the value of personalized tourniquet pressure. The pressure value of tourniquet, tourniquet use time, perioperative bleeding volume, VAS pain score of incision, VAS pain score of tourniquet site, circumference of tourniquet site, knee joint function (HSS) score, complications of tourniquet site and incision site complications were recorded and analyzed. [Results] The pressure value of tourniquet, postoperative drainage, occult blood loss, VAS score of incision on day 1 and 3, VAS score of tourniquet site and circumference of tourniquet site on day 1, 3 and 5 in the experimental group were significantly lower than those in the control group. The knee function score of the experimental group was significantly higher than that of the control group one week after operation (P<0.05). Complications of tourniquet site and incision site in the control group were lower than those in the experimental group (P<0.05). There was no significant difference in hemostatic effect and tourniquet usage time between the two groups (P>0.05). [Conclusion] The application of ultrasound Doppler ultrasound in setting the pressure value of individual tourniquet in total knee arthroplasty can not only ensure the hemostasis effect, but also effectively reduce the incidence of adverse reactions, so as to enhance the safety of using tourniquet and play an important role in the rapid recovery of patients.