Chronic low back pain is a common clinical disease with a huge cost of health care, In chronic low back pain, non-specific low back pain accounts for the majority of the total and its mechanism remains unclear. The development of animal models plays an important role in understanding the mechanism and procession of disease, This review is based on the anatomical structure of the lumbar spine and the development mechanism of the disease, divide the non-specific low back pain animal models into four categories: discogenic non-specific low back pain, radicular non-specific low back pain, inflammatory related non-specific low back pain, and gene related non-specific low back pain. At the same time, the evaluation methods of feedback pain in animal models(reflex behavioral change test and spontaneous behavioral change test)are briefly described in this review. It is hoped that by analyzing these animal models, we can figure out the pathogenesis and develop some better therapeutic regimens to treat the nonspecific low back pain in the future.