[Abstract] Objective To compare the clinical effect of treatment of unstable femoral trochanteric fracture with lateral locking plate and wire fixation. Methods Retrospective analysis of data of 83 patients with unstable femoral trochanteric fractures admitted to our hospital from March 2015 to December 2018, who were treated with intramedullary nail fixation and auxiliary lateral wall fixation. According to different methods of auxiliary external wall fracture fixation, 39 cases were divided into plate group and 44 cases were divided into wire group. The amount of blood loss , hospitalization days, cost of full weight bearing time, fracture healing time and surgical-related complications . Harris functional scores were graded 3, 6 and 12 months after surgery, Fracture reduction quality, fracture healing time, cervical Angle were observed in the two groups respectively. Result The locking plate group had a longer operation time (p=0.001) and higher cost (p=0.000) than the Cerclage wire group, but complete weight bearing time was short (p=0.005), fracture healing time was short (p=0.001), and Harris score grading 3 months after surgery (p=0.043) was better, Fracture reduction quality was better (p=0.034),and difference was statistically significant. In the locking plate group, there was 1 case of nonunion of posterior medial wall fracture, 2 cases of plate screw retreat, 2 cases of hip varus. In the cerclage wire group, there were 2 cases of fracture nonunion, 1 case of femoral head necrosis and 3 cases of hip varus. Conclusion The advantage of cerclage wire is that operation time is short and operation cost is relatively low. Proximal femoral locking plate can shorten time of full weight bearing and fracture healing, and improve early hip function. Fracture reduction quality is relatively good.