Objective: To evaluate the effectiveness of Ilizarov technique combined with limited surgery for severe neurogenic clubfoot deformity. Methods: According to the selection criteria, 28 males (32 feet) and 21 females (24 feet) who suffered neurogenic clubfoot deformity during June,2009 to Feb,2018 were chosen with an age vary from 11 to 35 years old (mean, 19.7 years). All of the cases are clinical data of Ilizarov technique combined with limited surgery for neurogenic clubfoot deformity from the first Affiliate Hospital of Zhengzhou University. Pathogeny: 33 clubfoot deformity patients in spastic palsy were because upper motor neuron injury caused by cerebral palsy and encephalitis, 10 clubfoot deformity patients in non spastic palsy were because spina bifida caused by meningocele of lumbosacral region, and 6 paralytic clubfoot patients were because lower motor neuron injury caused by various reasons. All patients were treated with selective soft tissue release, muscle balance and root bone osteotomy, weight-bearing area ulcer repairment while using Ilizarov technique to correct deformity, and they wore brace in neutral position three months later and reduced wearing time based on their conditions. The final follow up and preoperative AOFAS scores were counted and analyzed. Results: 49 cases (56 feet) were followed up in 6 to 36 months, with an average time of 21 months. All of the patients restored to line plantar foot without needle infection and nerve or vessel injury. Ulcers in the weight-bearing area were healed. At final follow-up, compared with preoperative score (32.48±16.073), the AOFAS of whole group scored 74.93±11.685. The difference was significant（t=-23.743，p=0.000）;Compared with preoperative score (31.18±16.602), the AOFAS of spastic group scored 76.68±10.369, which also was significant (t= -25.864，p=0.000); the AOFAS of no-spastic group scored 75.50±9.443 which was significantly higher（t= -9.539，p=0.000）than preoperative score(39.40±15.897); as for paralysis group, its final AOFAS scored 62.33±16.955 compared with preoperative score(29.67±10.857), and the difference also was significant(t= -3.670，p=0.014). Conclusion: The effectiveness of Ilizarov technique combined with limited surgery for various neurogenic clubfoot deformity is significant; personalized therapy should be made during treatment according to different patients and nursing and propaganda education should be valued after discharging from hospital.