Objective To investigate the clinical effect of cable reduction combined with intramedullary nail in the treatment of long oblique proximal femoral fractures. Methods The clinical data of 41 patients with long oblique proximal femoral fractures from May 2016 to December 2017 were retrospectively analyzed. Cable group was treated by minimally invasive implantation of titanium cable, cable reduction and intramedullary nail fixation. The control group was treated with traditional clamp reduction and intramedullary nail fixation. The clinical effects of the two groups were compared. Results There were significant differences in reduction times between the two groups (P<0.05); hip varus angle of the cable group was significantly lower than that of the control group (P<0.05), and fracture healing time was shorter (P<0.05); there were no significant differences in operation time, intraoperative bleeding volume and Harris score of hip joint in the two groups (P>0.05). Conclusion The curative effect of cable reduction is better than that of traditional clamp reduction, which can significantly improve the treatment effect and shorten the healing time of fracture.