[Objective] To study the effect of tibial transverse bone transport on Wagner 2-4 diabetic foot patients. [Method] Nineteen patients with diabetic foot who underwent tibial transverse bone transport from November 2017 to March 2018 were included. [Result] Except for 2 patients underwent amputations, 17 patients were followed up for 12-16 months (average 14.2 + 1.3 months). Among the 9 patients with peripheral vascular disease (PAD), 7 patients had significant relief of resting pain (P < 0.05), but ABI and foot skin temperature did not improve significantly (P > 0.05). In 16 patients with peripheral neuropathy, the results of 10g monofilament test showed no significant improvement (P > 0.05). The rates of ulcer healing, ulcer recurrence, tibial fracture, nail infection and amputation were 47.4% (9/19), 22.2% (2/9), 10.5% (2/19), 26.3% (5/19) and 10.5% (2/19), respectively. [Conclusion] Tibial transverse bone transport can effectively alleviate the symptoms of resting pain in diabetic foot in a short time, but the improvement of blood supply and nerve function needs further study. Diabetic foot is a disease caused by multiple factors, and it can not be expected to improve the symptoms of diabetic foot by tibial transverse bone transport alone.