Objective To summarize the experience of diagnosis and treatment of epileptic seizures in percutaneous endoscopic lumbar discectomy, analyze the causes, and explore the preventive and treatment measures. Methods From August 2014 to January 2018, 328 cases of epileptic seizures were found in 5 cases. There were 2 males and 3 females, aged 33~71 years(mean,45.5 ±12.3years). Hypertension in two cases. 1 cases were treated by intervertebral foramen approach. The operative segment was lumbar 4-5 intervertebral disc. 4cases were treated by interlaminar approach.The operative segment were lumbar 5- sacral 1 intervertebral disc. It occurred in sixth, twentieth, thirty-sixth, 85rd, and 193rd cases. To observe and record the diagnosis and treatment experience of epileptic seizures, analyze the causes, explore the treatment and preventive measures. Results 2 cases had epileptic seizures at the end of operation. They were removed from endoscopy, stopped washing, symptoms disappeared after close monitoring, and the symptoms of lumbago and leg pain disappeared after operation. 2 cases were discontinued, the endoscopy was removed, the flushing was stopped, the epileptic symptoms disappeared after close monitoring, and the two stage was treated with open surgery under general anesthesia. 1 cases of consciousness disturbance, deep slow breathing, after tracheal intubation, transferred to ICU after surgery, postoperative patients did not receive second operations and discharged from hospital. Dural sac rupture was found in 3 cases of interlaminar approach and 1 cases of intervertebral foramen approach. No dural sac was found in 1 patients. No residual head and neck pain was found after operation. The incision healed first and there was no cerebrospinal fluid leakage. Conclusion Dural sac rupture and increased epidural pressure are important causes of epileptic seizures during percutaneous endoscopic lumbar discectomy. Prevention and early detection are key.