Objective: To compare the clinical and radiologcal outcomes between multiple-point anchor by short screw and hybrid instrumentation for treatment of dystrophic scoliosis with neurofibromatosis type-1. Methods: From 2005 to 2017, multiple-point anchor by short screw (n=21) and hybrid instrumentation (n=21) were used for treatment of dystrophic scoliosis with neurofibromatosis type-1. At the preoperative, intraoperative, postoperative, and final follow-up stages, the following parameters were measured: coronal Cobb angle of main curve, flexibility, correction rate, corrective loss, apical vertebral translation (AVT), apical vertebral rotation (AVR), sagittal kyphosis (SK), operative time, blood loss, and fusion segment. The above parameters were analyzed and compared within?and?between?groups. Results: At preoperative stage, there was no statistical significance between two groups in coronal Cobb angle of main curve, flexibility, AVT, AVR, SK,operative time, blood loss, and fusion segment. Compared with preoperative, postoperative and final follow-up parameters showed significant improvement within?two?groups. At postoperative and final follow-up stages, there were significant differences between two groups in coronal Cobb angle of main curve, AVT, AVR, correction rate, corrective loss. The result of multiple-point anchor by short screw was obviously better than the result of hybrid instrumentation. Postoperative correction rates of multiple-point anchor by short screw and hybrid instrumentation were (67.1±9.0)% and (57.7±8.1)% respectively; corrective loss rates were (2.2±2.2)% and (3.6±1.4)% respectively. At postoperative and final follow-up stages, there was no statistical significance between two groups in SK. Conclusion: Multiple-point anchor by short screw and hybrid instrumentation for treatment of dystrophic scoliosis with neurofibromatosis type-1 could both yield satisfactory clinical efficacy. Multiple-point anchor by short screw provided a significantly better correction and lower corrective loss than hybrid instrumentation.