OBJECTIVE: To explore the effect and safety of SuperPATH approach in total hip arthroplasty (THA). METHODS: 116 patients with unilateral THA in our hospital from January 2013 to January 2018 were selected and divided into observation group and control group according to random number table. The observation group was operated by SuperPATH approach, while the control group was operated by traditional posterolateral approach. The clinical data was compared between two groups. RESULTS: The incision length, intraoperative bleeding volume and operation time in the observation group were lower than those in the control group (P<0.05). The drainage volume, weight-bearing time and hospitalization time of the observation group were lower than those of the control group (P<0.05). The VAS score of pain and Harris score of affected hip in the observation group were lower than those in the control group at 1 and 3 months after operation, and the Harris score of affected hip was higher than that in the control group (P<0.05). The VAS score of pain and Harris score of affected hip in the two groups changed with time (P<0.05). There was interaction between grouping and time (P<0.05). CONCLUSIONS: Compared with conventional posterolateral approach, SuperPATH approach for THA has the advantages of shorter operation time and faster recovery after operation. It conforms to the concept of minimally invasive surgery and is worth popularizing.