【Abstract】Objective: To explore clinical application and preliminary outcome analysis of PEEK（polyetheretherketone，PEEK） rod dynamic stabilization system combined with hybrid surgery in treatment of lumbar degenerative diseases. Methods: Retrospective analysis the clinical data of patients with lumbar degenerative diseases admitted to our hospital from March 2014 to June 2017.Including 8 males and 12 females with an average age of 68.2 years (range 55-83 years) , the disease level is from L3 to S1.Surgical procedures including hybrid surgery and dynamic stabilization with PEEK rod system were performed. The VAS, ODI and Stauffer-Coventry value standard were scored to evaluate the clinical efficacy. Range of motion (ROMs) , disc space height(DSH）of each adjacent instrumented levels(one segment above the instrumentation )were measured before and after operation to evaluate the degeneration of adjacent disk .Results: The average follow up period was 12-39 months (average18.5months). All the incisions healed by first intention. The scores of VAS and ODI were significantly improved at 6 months and at the end of follow-up (P<0.001). At the last follow-up, according to Stauffer-Coventry evaluation criteria, clinical efficacy was excellent in 15 cases, good in 3 cases, medium in 2 case, poor in 0 cases, the excellent and good rate was 90%. No postoperative complications such as internal fixation fracture, loosening and neurological impairment occurred. There was no significant difference in DSH and ROM between adjacent segments 6 months after operation and at the last follow-up (P > 0.05). Conclusions: PEEK rod dynamic stabilization system combined with hybrid surgery in the treatment of lumbar degenerative diseases with satisfactory early clinical results. It provides a new choice for the surgical treatment of senile lumbar degenerative diseases, especially multi-level lumbar degenerative diseases, with shorter operation time, less bleeding and less trauma, but its long-term effect still needs further clinical control study.