【Abstract】 Objective To Analysis the short-term clinical efficacy of fixed-bearing unicompartmental knee arthroplasty for medial unicompartment osteoarthritis. Methods During the period 2016/7 to 2018/5 a total of 79 patients（91 knees）underwent fixed-bearing unicompartmental knee arthroplasty for medial unicompartment osteoarthritis.The average age was （57.39±4.64）years（49-86 years）. All cases were performed by the same surgery team. The medial unicompartment osteoarthritis was treated with anterior medial and small incision and multimodal analgesia.Follow-up made by telephone or outpatient.The median follow-up was （14.36±7.58）（range 7 to 30 months）and none of the patients died, and 2 were considered to be lost.The patients were evaluated pre- and postoperatively by KSS scoring system, and the data were analyzed statistically. Results The mean KSS knee scores pre-and postoperatively was （65.44±5.48）（range 50 to 82）to （97.31±1.36）（89 to 100） , the mean KSS function scores pre-and postoperatively was （54.57±6.11）（range 44 to 78） to （94.83±1.28）（80 to 100） ,P<0.05.1 case occurred tibial plateau fracture in the operation and 1 case was weakness on knee extension of postoperation.2 cases presented intractable pain.There was no lateral compartments progressive degeneration cases. Conclusion The treatment of fixed-bearing medial unicompartmental knee arthroplasty is effective in the short-term clinical efficacy.