OBJECTIVE: To investigate the incidence and risk factors of non-specific low back pain (LBP) among the employees of the Zhuang Youth Office in Guangxi. METHODS: A self-administered questionnaire survey was conducted on a statistical project, anthropometry, related factors and non-specific low back pain characteristics of 2,876 Zhuang Youth Offices. LBP assessment and risk factor analysis are based on self-questionnaires. RESULTS: The study found that the incidence of non-specific low back pain in the Zhuang Youth Office was 65.71% (P < 0.001) within 3 months prior to the survey. Among them, smoking (P < 0.001), nightmares (P < 0.001), poor self-assessment (P < 0.001), history of previous low back pain (P < 0.001) and LBP family history (P < 0.001) were independently associated. Conclusion: LBP is very common among Zhuang youth office staff. The risk factors include poor sleep quality, smoking, nightmares, poor self-evaluation, LBP individual history, and LBP family history. LBP has no connection with only children, registered households or physical activity.