[Objective] To compare the efficacy of a new compression hook plate and PHILOS plate in the treatment of fractures of the humerus greater tuberosity. [Methods] A retrospective analysis of 25 patients with fractures of the humerus greater tuberosity who were admitted to our hospital from February 2016 to December 2017. the patients were divided into two groups according to different fixation methods. The new compression hook plate group consisted of 12 patients, 7 males and 5 females, aged 26-64 years, mean 44.1 years old; 13 patients in the PHILOS plate group, 9 males and 4 females, aged 32-62 years, mean 43.6 years old. The length of the incision, the amount of bleeding, the time of surgery, the incidence of complications, and the time to union were recorded. The postoperative outcomes of the two groups were evaluated primarily by the American Shoulder and Elbow Surgeon Score (ASES) and the Constant-Murley Scoring System (CMS). [Results] The follow-up time of the two groups was 12-20 months, with an average of 14.3 months. During the follow-up period, there was no incision adverse event, neurovascular injury, delayed fracture union and other complications in the new compression hook plate group. There was no significant difference in the incidence of complications between the two groups (p>0.05). The compression hook plate group was superior to the PHLIOS group in length of incision, intraoperative blood loss and operation time, and the difference was statistically significant (p<0.05). The fracture union time of the two groups was comparable, and there was no statistically significant difference (p>0.05). At the final follow-up, the ASES and CMS scores of the new compression hook plate group were better than those of the PHLIOS group, and the difference was statistically significant (p<0.05). [Conclusion] Compared with PHILOS plate, the new compression hook plate for the treatment of fractures of the humerus greater tuberosity has the advantages of small incision, less trauma, less postoperative complications and better recovery of shoulder function.