：Osteoarthritis (OA) is a degenerative joint disease that affects a large number of people. The mechanism of this highly prevalent disease is still at a hot stage. Matrix metalloproteinase (MMP)-13 has a critical rate-limiting function in cartilage remodeling and degradation due to its specificity for cleavage of type II collagen, and skeletal development and bone remodeling can be regulated in a variety of ways and in multiple pathways. This article reviews the regulation of MMP13 in osteoarthritis, related signaling pathways, and advances in clinical research.